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| 产品名称 | PDGFRα Mouse Monoclonal Antibody(7A3) | 反应种属 | H,R,M |
| 应用 | IHC | ||
| 配方 | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. | ||
| 别称 | |||
| 储存 | -20°C. Do not aliquot the antibody. | ||
| 推荐稀释比 | IHC: 1:100-200 Optimal dilutions should be determined by the end user. | ||
| 特异性 | The antibody can detects endogenous PDGFRα proteins. | ||
| 背景信息 | Platelet derived growth factor (PDGF) family proteins exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC, and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). PDGFRα and PDGFRβ can each form heterodimers with EGFR, which is also activated by PDGF. Various cells differ in the total number of receptors present and in the receptor subunit composition, which may account for responsive differences among cell types to PDGF binding. Ligand binding induces receptor dimerization and autophosphorylation, followed by binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules, such as GRB2, Src, GAP, PI3 kinase, PLCγ, and NCK. A number of different signaling pathways are initiated by activated PDGF receptors and lead to control of cell growth, actin reorganization, migration, and differentiation. | ||
| 分子量 | ~180KD | 同型 | IgG1 |
| GeneID | 5156 | 理论分子量 | 180 |
| SWISS | P16234 | 宿主物种 | Mouse |
| 免疫原 | Synthetic Peptide | 克隆性 | Monoclonal |
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Immunohistochemical analysis of paraffin-embedded Rat Skin Tissue using PDGFR a Mouse mAb diluted at 1:200.
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Immunohistochemical analysis of paraffin-embedded Human Skin Tissue using PDGFR a Mouse mAb diluted at 1:200.