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| 产品名称 | NFkB p65 Mouse Monoclonal Antibody (14H2) | 反应种属 | H,M,R |
| 应用 | WB, IHC, IP | ||
| 配方 | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. | ||
| 别称 | |||
| 储存 | -20°C. Do not aliquot the antibody. | ||
| 推荐稀释比 | WB: 1:1,000-3,000 IHC: 1:200 IP:1:200 Optimal dilutions should be determined by the end user. | ||
| 特异性 | NFκB p65 Mouse monoclonal antibody detects endogenous p65 proteins. | ||
| 背景信息 | NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection. | ||
| 分子量 | ~65KD | 同型 | IgG1 |
| GeneID | 5970 | 理论分子量 | 65 |
| SWISS | Q04206 | 宿主物种 | Mouse |
| 免疫原 | Synthetic Peptide | 克隆性 | Monoclonal |
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Western blot analysis of 1) Hela, 2)293T,3)HepG with NFκB p65 mAb diluted at 1:2,000.
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IHC staining of mouse hippocampus tissue with NFκB p65 mouse mAb(14H2) diluted at 1:200.