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| 产品名称 | Claudin-2 Mouse Monoclonal Antibody（8H11） | 反应种属 | H, R, M |
| 应用 | WB,IHC | ||
| 配方 | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. | ||
| 别称 | Claudin2,CLDN2,SP82 | ||
| 储存 | -20°C. Do not aliquot the antibody. | ||
| 推荐稀释比 | WB: 1:1,000~2,000 IHC：1:100~200 Optimal dilutions should be determined by the end user. | ||
| 特异性 | Claudin-2 antibody detects endogenous Claudin-2 proteins. | ||
| 背景信息 | The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation . | ||
| 分子量 | 25KD | 同型 | IgG1 |
| GeneID | 9075 | 理论分子量 | 25 |
| SWISS | P57739 | 宿主物种 | Mouse |
| 免疫原 | Synthetic Peptide | 克隆性 | Monoclonal |
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Western blot analysis of 1) Hela Cell Lysate, 2) Mouse Heart Tissue Lysate , 3) Rat Heart Tissue Lysate using Claudin-2 Mouse mAb diluted at 1:2000.
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Immunohistochemical analysis of paraffin-embedded Human Kidney Carcinoma Tissue using Claudin-2 Mouse mAb diluted at 1:200.